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10x Genomics Launches New Chromium Flex for Single-Cell Research

New plate-based multiplexing unlocks ultra-high-sample and cell-throughput single cell analysis to empower a broad range of studies.

By: Rachel Klemovitch

Assistant Editor

10x Genomics, Inc., a leader in single-cell and spatial biology, launched the next generation of its Flex assay, featuring automation-compatible plate-based multiplexing. 

The new assay delivers cost-effective, highly scalable single-cell analysis, empowering researchers to explore a broad range of studies—from high cell-number applications, such as functional genomics, CRISPR screens, and high-sample-number applications, like FFPE-based translational studies. 

With the new assay, researchers can profile up to 384 samples and 100 million cells per week using a 96-well plate format that integrates with 10x’s automated cell partitioning. 

Built on 10x’s proven Flex chemistry, the assay delivers sensitivity and sequencing efficiency in a scalable workflow. Its automation-compatible, plate-based multiplexing supports modular usage, enabling experimental flexibility and scale while reducing reagent waste.

Early access customers have begun using new Flex across a range of discovery and translational research programs.

“As we increase scalability and ease of use, researchers are unlocking more – more samples, more conditions, more insights – at a fraction of the previous cost. And as AI-driven approaches evolve, the need for high-quality biological data is only accelerating,” said Michael Schnall-Levin, Founding Scientist and Chief Technology Officer at 10x Genomics. “This next generation of Flex represents a transformational step forward in enabling large scale, foundational and translational studies, as well as routine single-cell use.”

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